Fengzhi Li, Tao Jiang, Qingyong Li, Xiang Ling: Camptothecin (CPT) and its derivatives are known to target topoisomerase I (Top1) as their mechanism of action: did we miss something in CPT analogue molecular targets for treating human disease such as cancer? Am J Cancer Res 2017;7(12):2350-2394. (Full text, PDF, Supplementary Data)
Xuedong Fu, Wei Liu, Qian Huang, Yanjun Wang, Huijuan Li, Ying Xiong: Targeting mitochondrial respiration selectively sensitizes pediatric acute lymphoblastic leukemia cell lines and patient samples to standard chemotherapy. Am J Cancer Res 2017;7(12):2395-2405. (Full text, PDF)
Xiulei Zhang, Qinyue Chen, Meiyu Chen, Xiaoqing Ren, Xiaofei Wang, Jianghui Qian, Yali Sun, Xianyi Sha: Ambroxol enhances anti-cancer effect of microtubule-stabilizing drug to lung carcinoma through blocking autophagic flux in lysosome-dependent way. Am J Cancer Res 2017;7(12):2406-2421. (Full text, PDF)
Holli A Loomans, Shanna A Arnold, Kate Hebron, Chase J Taylor, Andries Zijlstra, Claudia D Andl: Loss of ACVRIB leads to increased squamous cell carcinoma aggressiveness through alterations in cell-cell and cell-matrix adhesion proteins. Am J Cancer Res 2017;7(12):2422-2437. (Full text, PDF)
Lin-Xin Zhang, Lu Xu, Chen-Han Zhang, Yi-Han Lu, Tian-Hao Ji, Li-Jun Ling: uc.38 induces breast cancer cell apoptosis via PBX1. Am J Cancer Res 2017;7(12):2438-2451. (Full text, PDF)
Niroshaathevi Arumuggam, Nicole Melong, Catherine KL Too, Jason N Berman, HP Vasantha Rupasinghe: Phloridzin docosahexaenoate, a novel flavonoid derivative, suppresses growth and induces apoptosis in T-cell acute lymphoblastic leukemia cells. Am J Cancer Res 2017;7(12):2452-2464. (Full text, PDF)
Ping-Ting Gao, Jian-Wen Cheng, Zi-Jun Gong, Bo Hu, Yun-Fan Sun, Ya Cao, Shuang-Jian Qiu, Jian Zhou, Jia Fan, Xin-Rong Yang: Low SLC29A1 expression is associated with poor prognosis in patients with hepatocellular carcinoma. Am J Cancer Res 2017;7(12):2465-2477. (Full text, PDF)
Hannah M Jones, Ziwei Fang, Wenchuan Sun, Leslie H Clark, Jessica E Stine, Arthur-Quan Tran, Stephanie A Sullivan, Timothy P Gilliam, Chunxiao Zhou, Victoria L Bae-Jump: Atorvastatin exhibits anti-tumorigenic and anti-metastatic effects in ovarian cancer in vitro. Am J Cancer Res 2017;7(12):2478-2490. (Full text, PDF)
Chao Jing, Xin Qu, Zhaoqing Li, Chuanqiang Wu, Minghui Zhao, Yu Wang, Shanshan Sun, Shengchi Zhang, Jinliang Chen, Yu Qiao, Xiaomeng Hu, Xiaofeng Yao, Rui Jin, Xudong Wang, Lun Zhang, Xuan Zhou: EGFRwt/vIII-PKM2-β-catenin cascade affects proliferation and chemo-sensitivity in head and neck squamous cell carcinoma. Am J Cancer Res 2017;7(12):2491-2502. (Full text, PDF)
Wanhu Zhu, Qing Liang, Xu Yang, Yan Yu, Xiaoying Shen, Guangchun Sun: Combination of sorafenib and Valproic acid synergistically induces cell apoptosis and inhibits hepatocellular carcinoma growth via down-regulating Notch3 and pAkt. Am J Cancer Res 2017;7(12):2503-2514. (Full text, PDF)
Guanghua Liu, Zixing Ye, Xin Zhao, Zhigang Ji: SP1-induced up-regulation of lncRNA SNHG14 as a ceRNA promotes migration and invasion of clear cell renal cell carcinoma by regulating N-WASP. Am J Cancer Res 2017;7(12):2515-2525. (Full text, PDF)
Hailin Zhang, Ming Bai, Ang Zeng, Loubin Si, Nanze Yu, Xiaojun Wang: LncRNA HOXD-AS1 promotes melanoma cell proliferation and invasion by suppressing RUNX3 expression. Am J Cancer Res 2017;7(12):2526-2535. (Full text, PDF)
Li-Guo Zhang, Xin-Ke Zhou, Ru-Jian Zhou, Hui-Zeng Lv, Wei-Peng Li: Long non-coding RNA LINC00673 promotes hepatocellular carcinoma progression and metastasis through negatively regulating miR-205. Am J Cancer Res 2017;7(12):2536-2544. (Full text, PDF)
Yanjun Xu, Rui Hou, Qijie Lu, Yang Zhang, Lei Chen, Yuanyi Zheng, Bing Hu: MiR-491-5p negatively regulates cell proliferation and motility by targeting PDGFRA in prostate cancer. Am J Cancer Res 2017;7(12):2545-2553. (Full text, PDF)
Haolei Tan, Gangcai Zhu, Li She, Ming Wei, Yunyun Wang, Leiming Pi, Changhan Chen, Diekuo Zhang, Pingqing Tan, Jie Chen, Donghai Huang, Yongquan Tian, Yong Liu, Xin Zhang: MiR-98 inhibits malignant progression via targeting MTDH in squamous cell carcinoma of the head and neck. Am J Cancer Res 2017;7(12):2554-2565. (Full text, PDF)
Peter J Esau, Elizabeth M Gittemeier, Alexander B Opoku-Acheampong, Korynne S Rollins, Dryden R Baumfalk, David C Poole, Timothy I Musch, Bradley J Behnke, Steven W Copp: Prostate cancer reduces endurance exercise capacity in association with reductions in cardiac and skeletal muscle mass in the rat. Am J Cancer Res 2017;7(12):2566-2576. (Full text, PDF)
Kazuaki Matsuoka, Teiji Takechi: Combined efficacy and mechanism of trifluridine and SN-38 in a 5-FU-resistant human colorectal cancer cell lines. Am J Cancer Res 2017;7(12):2577-2586. (Full text, PDF)
Krittiya Korphaisarn, Chao-Kai Chou, Wei-Ya Xia, Callisia N Clarke, Riham Katkhuda, Jennifer S Davis, Kanwal PS Raghav, Hsin-Wei Liao, Ji-Yuan Wu, David G Menter, Dipen M Maru, Mien-Chie Hung, Scott Kopetz: Arginine methylation of EGFR: a new biomarker for predicting resistance to anti-EGFR treatment. Am J Cancer Res 2017;7(12):2587-2599. (Full text, PDF)
